06.01 Clopidogrel (Plavix)

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Generic Name

Clopidogrel

Trade Name

Plavix

Indication

Atherosclerotic events, MI, CVA, PVD, acute coronary syndrome

Action

Inhibits platelet aggregation

Therapeutic Class

Antiplatelet agent

Pharmacologic Class

Platelet aggregation inhibitors

Nursing Considerations

• May cause GI bleeding, neutropenia, hypercholesterolemia
• May increase risk for bleeding in warfarin, aspirin, heparin
• Can increase risk for bleeding with garlic, ginkgo, ginger
• Monitor for signs of bleeding
• Monitor bleeding times
• Monitor CBC and platelet count
• Discontinue use 5-7 days before surgery

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