06.05 Alteplase (tPA, Activase)

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Generic Name


Trade Name

tPA, Activase


MI, acute ischemic stroke, occluded central lines


Converts plasminogen to plasmin which degrades the fibrin found in clots

Therapeutic Class


Pharmacologic Class

Plasminogen activators

Nursing Considerations

• Contraindicated in active bleeding
• Monitor closely for signs of bleeding (petechiae)
○ q 15 min X1hr o q 15-30 min X 8 hr
• Use caution with patient who have had recent surgery
• May cause intracranial hemorrhage
• Monitor for anaphylaxis
• Use caution with uncontrolled hypertension
• Assess neuro status during therapy

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