07.02 Divalproex (Depakote)

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Generic Name

Divalproex

Trade Name

Depakote

Indication

Seizures, manic episodes, prevention of headache

Action

Increases the level of GABA (inhibitory neurotransmitter) in CNS

Therapeutic Class

Anticonvulsant, vascular headache suppressants

Pharmacologic Class

None

Nursing Considerations

• May cause suicidal thoughts, agitation, dizziness, insomnia, hepatotoxicity,
pancreatitis
• Increases risk for bleeding with Warfarin
• Use caution with MAOIs
• Monitor liver function tests

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