08.07 Fluoxetine (Prozac)

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Generic Name

Fluoxetine

Trade Name

Prozac

Indication

Depressive disorder, OCD, bulimia, panic disorder, bipolar, anorexia, ADHD, DM
neuropathy, obesity

Action

Inhibits reuptake of serotonin allowing it to persist longer in the synaptic cleft

Therapeutic Class

Antidepressant

Pharmacologic Class

SSRI

Nursing Considerations

• Do not use while taking MAOIs
• May cause suicidal thoughts, drowsiness, anxiety, sexual dysfunction,
insomnia, palpitations
• Monitor closely for serotonin syndrome
• Concurrent use with certain medications may lead to QT prolongation
• Monitor mood changes and assess for suicidal ideation
• Monitor nutrition status
• May cause elevated liver enzymes
• Instruct pt to maintain good oral hygiene

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