08.11 Amitriptyline (Elavil)

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Generic Name


Trade Name



Depression, anxiety, insomnia, parkinson’s


Increases effect of serotonin and norepinephrine in the CNS, exhibits anticholinergic effects

Therapeutic Class


Pharmacologic Class

Tricyclic antidepressant

Nursing Considerations

• Contraindicated in MI, heart failure, QT prolongation, glaucoma
• May increase risk for suicidal ideation
• May cause arrhythmias, hypotension, EKG changes
• May cause alterations in blood glucose levels
• May lead to general sedation and lethargy
• Do not use within 2 weeks of MAOIs
• Instruct pt to take medication exactly as instructed
• Monitor for orthostatic hypotension
• May lead to photosensitivity, instruct patient to use sunscreen
• May turn urine blue/green color.

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