10.02 Diphenhydramine (Benadryl)

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Generic Name


Trade Name



Allergy, anaphylaxis, sedation, motion sickness, antitussive


Antagonizes effects of histamine, CNS depression

Therapeutic Class

Allergy, cold and cough remedy, antihistamine, antitussive

Pharmacologic Class


Nursing Considerations

• May cause drowsiness, anorexia, dry mouth, nausea, chest tightness, thick
secretions, hypotension, blurred vision, headache
• Anticholinergic effects (dry mouth, blurred vision, constipation, sedation)
• Assess purpose of medication prior to giving it
• Assess allergies, sleep patterns, cough and lung sounds
• Patient should avoid other over-the-counter cough and cold remedies

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