10.05 Cimetidine (Tagamet)

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Generic Name


Trade Name



Treatment of duodenal ulcers, GERD, heartburn, Zollinger Ellison syndrome,
prevention of GI bleeding in critical patients.


Inhibits action of histamine leading to inhibition of gastric acid secretion

Therapeutic Class

Antiulcer agent

Pharmacologic Class

Histamine H2 antagonist

Nursing Considerations

• Increases serum level of warfarin
• Can lead to respiratory infection (green sputum)
• Monitor for arrhythmias
• May cause agranulocytosis, aplastic anemia
• Monitor CBC during therapy
• Take medication as directed
• Instruct patient to increase fluid and fiber intake to decrease constipation

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