11.13 Diltiazem (Cardizem)

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Generic Name


Trade Name



Hypertension, angina, SVT, AFib, aflutter


Inhibits calcium transport resulting in inhibition of excitation and contraction,
leads to depression of AV and SA node leading to decreased HR, leads to vasodi-
latation and decreased blood pressure.

Therapeutic Class

Antianginals, antiarrhythmics, antihypertensive

Pharmacologic Class

Ca Channel Blocker (Benzothiazepine)

Nursing Considerations

• Contraindicated in 2nd and 3rd AV block
• May cause arrhythmias, CHF, bradycardia, peripheral edema, gingival
• Increases digoxin levels
• Don’t drink grapefruit juice
• Assess for signs of CHF
• Monitor EKG continuously
• Tell patient to change positions slowly
• Monitor serum potassium
• Instruct pt on how to take blood pressure

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