14.06 Carbidopa-Levodopa (Sinemet)

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Generic Name

Carbidopa/levodopa

Trade Name

Sinemet

Indication

Parkinson’s disease

Action

Levodopa is converted to dopamine and works as a neurotransmitter, carbidopa
prevents the destruction of levodopa allowing it to cross the blood brain barrier

Therapeutic Class

Antiparkinson agent

Pharmacologic Class

Dopamine Agonist

Nursing Considerations

• May cause orthostatic hypotension
• May cause dark urine
• Weeks to months to take effect
• Do not use with MAOIs
• Do not use with glaucoma, melanoma
• Assess for parkinsonian symptoms
• Instruct patient to take as directed

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