18.07 Cyclosporine (Sandimmune)

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Generic Name


Trade Name



Prevention of rejection in transplantation, treatment of severe RA, management
of ulcerative colitis


Inhibits normal immune response primarily by decreasing the activity of T cells

Therapeutic Class

Immunosuppressant, antirheumatics (DMARD)

Pharmacologic Class

Polypeptides (cyclic)

Nursing Considerations

• May cause seizures, tremors, hypertension, hepatotoxicity, diarrhea, N/V,
gingival hyperplasia
• Increases immune suppression with corticosteroids
• Avoid grapefruit juice while taking this medications
• Assess for signs of organ rejection
• Monitor renal panel, liver enzymes
• Take medication as directed
• Lifelong therapy required for transplant patients
• Instruct pt on how to take blood pressure

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