12.04 Isoniazid (Niazid)

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Generic Name

isoniazide

Trade Name

INH

Indication

tuberculosis

Action

Inhibits synthesis of mycobacterial cell wall

Therapeutic Class

Antitubercular

Pharmacologic Class

none

Nursing Considerations

• can cause jaundice
• may cause peripheral neuropathy, seizures, hepatitis
• patient should avoid high amounts of tyramine (pickled meats, aged/smoked meats, alcohol, exotic/aged cheese)
• monitor liver function tests
• complete full course of therapy (6-12 months)
• often used in combination with Rifampin

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