24.07 Meperidine (Demerol)

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Generic Name


Trade Name



moderate to severe pain, sedation


Binds to opiate receptors in the CNS and alters perception of pain while producing a general depression of the CNS.

Therapeutic Class

Opioid Analgesic

Pharmacologic Class

opioid agonists

Nursing Considerations

• may cause alterations in mentation, hypotension, constipation, nausea, vomiting
• assess BP, pulse, and respiratory rate prior to administration and frequently during
• use caution if patient is receiving MAOIs
• Narcan (naloxone) is the antidote for opioid agonists
• can cause seizure
• may increase pancreatic enzyme levels
• assess bowel function

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