24.08 Methadone (Methadose)

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Generic Name


Trade Name



withdrawal symptoms, pain


Suppresses withdrawal symptoms. Binds to opiate receptors in the CNS and alters perception of pain while producing a general depression of the CNS. This depression also causes a decrease in the cough reflex and GI motility.

Therapeutic Class

opioid analgesic

Pharmacologic Class

opioid agonist

Nursing Considerations

• use caution if patient is receiving MAO Inhibitors
• may cause QT prolongation, hypotension, respiratory depression, dependence, confusion, sedation
• assess pain, vital signs, bowel function
• may increase pancreatic enzyme levels
• assess withdrawal symptoms

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