14.08 Neostigmine (Prostigmin)

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Generic Name


Trade/Brand Name



  • Myasthenia gravis
  • Muscle relaxant reversal


  • Blocks action of acetylcholinesterase
    • Increases level of acetylcholine

Therapeutic Class

Muscle stimulant

Pharmacologic Class

Cholinesterase inhibitor

Nursing Considerations

  • May cause
    • Weakness
    • Hypotension
    • Allergic reactions
    • Muscle twitching
  • Symptoms of overdose
    • Constipation
    • Difficult urination
    • Decreased sexual ability
  • Contraindications
    • Hypersensitivity
    • Peritonitis
    • Mechanical obstruction of intestinal or urinary tract

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