17.06 Ondansetron (Zofran)

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Generic Name

ondansetron

Trade Name

Zofran

Indication

nausea/vomiting

Action

blocks effects of serotonin on vagal nerve and CNS

Therapeutic Class

antiemetic

Pharmacologic Class

5-HT3 antagonist

Nursing Considerations

• administer slowly over 2-5 minutes – fatal QT prolongation and VTach, respiratory arrest
• may cause headache, constipation, diarrhea, dry mouth
• asses nausea and vomiting
• assess for extrapyramidal symptoms
• monitor liver function tests

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