10.03 Promethazine (Phenergan)

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Generic Name

promethazine

Trade Name

Promethacon

Indication

allergic reactions, nausea and vomiting, sedation

Action

Blocks the effects of histamine, histamine plays a role in the immune response.  Plays an inhibitory role on the chemoreceptor trigger zone in the medulla leading to an antiemetic effect.  Possess anticholinergic properties producing CNS depression.

Therapeutic Class

antiemetic, antihistamine, sedative/hypnotic

Pharmacologic Class

phenothiazine

Nursing Considerations

• IV administration may cause damage to tissue, hypertension, impaired liver function
• monitor for neuroleptic malignant syndrome, confusion, sedation
• may cause CNS depression
• assess sedation level and anticholinergic effects

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