10.03 Promethazine (Phenergan)

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Generic Name


Trade Name



allergic reactions, nausea and vomiting, sedation


Blocks the effects of histamine, histamine plays a role in the immune response.  Plays an inhibitory role on the chemoreceptor trigger zone in the medulla leading to an antiemetic effect.  Possess anticholinergic properties producing CNS depression.

Therapeutic Class

antiemetic, antihistamine, sedative/hypnotic

Pharmacologic Class


Nursing Considerations

• IV administration may cause damage to tissue, hypertension, impaired liver function
• monitor for neuroleptic malignant syndrome, confusion, sedation
• may cause CNS depression
• assess sedation level and anticholinergic effects

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