08.09 Sertraline (Zoloft)

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Generic Name

sertraline

Trade Name

Zoloft

Indication

major depressive disorder, OCD, anxiety

Action

inhibits uptake of serotonin allowing for higher quantities available within synaptic cleft

Therapeutic Class

Antidepressant

Pharmacologic Class

SSRI

Nursing Considerations

• do not use with MAOIs
• can cause neurolyptic malignant syndrome, suicidal thoughts, drowsiness, insomnia, diarrhea,
dry mouth, tremors, serotonin syndrome, sexual dysfunction
• monitor mood changes in patient
• takes 1-4 weeks for therapy to be effective.

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