12.20 Trimethoprim-Sulfamethoxazole (Bactrim)

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Generic Name

trimethoprim/sulfamethoxazole

Trade Name

Bactrim/TMP-SMZ

Indication

bronchitis, UTI, diarrhea, pneumonia, multiple types of infection

Action

bacteriacidal by preventing metabolism of folic acid

Therapeutic Class

anti-infectives, antiprotozoals

Pharmacologic Class

folate antagonists, sulfonamides

Nursing Considerations

• may cause renal damage, Steven Johnsons Syndrome – rash, pseudomembranous colitis, nausea,
vomiting, diarrhea, rash, agranulocytosis, aplastic anemia, phlebitis
• contraindicated with sulfa allergies
• monitor CBC
• obtain cultures prior to initiating therapy
• monitor intake and output
• instruct patient to complete dose
• drink 8-10 glasses of water

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