06.02 Warfarin (Coumadin)

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Generic Name


Trade Name



venous thrombosis, pulmonary embolism, A-fib, myocardial infarction


disrupts liver synthesis of Vitamin K dependent clotting factors

Therapeutic Class


Pharmacologic Class


Nursing Considerations

• contraindicated with bleeding, severe hypertension
• can cause bleeding
• aspirin and NSAIDs can increase risk of bleeding
• azole antifungals increase effects of warfarin
• cimetadine(Tagamet) increases warfarin levels
• obtain full history of supplements and herbs
• large amounts of vitamin K may antagonize effects of warfarin
• assess for signs of bleeding
• therapeutic levels: PT 1.3-1.5, INR 2.5-3.5
• instruct patient to report any signs of bleeding
• patient should not drink alcohol
• bleeding times need to be monitored frequently
• vitamin K is antidote

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  • Question 1 of 2

A client is taking warfarin for a clotting disorder. Which of the following dietary restrictions should the nurse include while educating this client about warfarin? Select all that apply.

  • Question 2 of 2

A nurse is preparing to administer a dose of warfarin to a client. Based on the nurse’s knowledge of this drug, the nurse knows to monitor for which of the following side effects?

Module 0 – Pharmacology Course Introduction

Module 3 – Disease Specific Medications

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